Guillotine |
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Isaac's head is removed from his body and floats around him. Increases Damage by 1 and Tears by 0.16. |
Guppy's Collar |
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50% chance to respawn with 1/2 heart after death. |
Guppy's Hair Ball |
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Loosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies. |
Guppy's Tail |
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Increases chance of gold chests and normal chests. |
Habit |
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When Isaac is hit, 1 point of an item's charge is filled. |
The Halo |
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Grants one Heart Container,+0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed and +0.5 Tear Height |
Halo Of Flies |
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Spawns two pretty fly familiars that block enemy shots and deal contact damage to enemies. |
Harlequin Baby |
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Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern. |
Headless Baby |
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Familiar that follows Isaac, leaving blood creep on the ground. |
Hive Mind |
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Increases the size of blue spiders and flies and doubles their damages. |
Holy Grail |
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Grants flight and one heart container. |
Holy Mantle |
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Automatically negates first taken damage in every room. |
Holy Water |
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When Isaac receives damage, the bottle breaks and a puddle of blue Creep forms, which damages non-flying enemies, similar to Lemon Mishap. The bottle is reformed upon entering a different room. |
Hot Bombs |
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Grants 5 bombs and applies burning blast effect. |
Humbling Bundle |
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Gives one extra pickup (1+1 Free version) of Red Hearts, pennies, bombs and Keys. Does not work with blue, black and half red hearts, nickels and dimes. |
Infamy |
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A brown/grey mask. Damage reduction. Can block projectiles on the side Isaac is facing. |
Infestation |
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1-3 Blue Flies randomly spawn every time Isaac gets hit. |
Infestation 2 |
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Grants an infestation shot that spawns allied blue spiders from killed enemies. |
The Inner Eye |
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Grants a triple shot but greatly decreases tears. |
Ipecac |
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Replaces tears with explosive and poisoning projectiles fired in an arc from the mouth. |
Iron Bar |
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Increases damage by 0.3 and adds a chance to shoot concussive tears, causing enemies to walk around randomly. |
Isaac's Heart |
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Isaac himself is now immune to all damage, and a heart familiar appears and follows Isaac. If the heart is hurt, Isaac is hurt. |
Jesus Juice |
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Increases Damage and Range. |
Judas' Shadow |
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Adds an extra life; upon death, it respawns Isaac as Judas' Shadow with only two black hearts. |
Juicy Sack |
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A Familiar that follows behind Isaac. It drips a trail of creep, which slows enemies, and spawns 1-2 Blue Spiders after each room. |
Key Piece 1 |
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Combined with Key Piece 2, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan. |
Key Piece 2 |
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Combined with Key Piece 1, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan. |
The Ladder |
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Allows Isaac to walk across gaps one square across by automatically placing a ladder between the two walkable sections. |
Latch Key |
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Increases Luck by 1, grants 1 Soul Heart and spawns 2 Keys. |
Lazarus' Rags |
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Upon dying, resurrect with one heart container and Anemic item. |
Leech |
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Spawns a friendly familiar leech on the ground that hunts down enemies and heals you for half a heart each time it eats one. |
Leo |
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Allows you to crush rocks when you walk over them |
Libra |
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Gives 6 coins, 6 bombs and 6 keys and balances out all attributes. |
Lil' Brimstone |
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A Familiar that shoots a small Brimstone beam. Must charge like the Brimstone Item before shooting. |
Lil' Haunt |
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A familiar that damages enemies by chasing them as well as inducing the fear effect. |
Little Baggy |
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Gives Isaac a random Pill and add a slot pill |
Little C.H.A.D. |
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A Familiar who will drop a half Heart every 2 rooms. |
Little Chubby |
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A Familiar that charges forward and deals touch damage to any enemies in her path. Will attack when the Isaac attacks with a moderate cooldown time before she can attack again. |
Little Gish |
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Spawns a familiar that follows Isaac around and fires slowing tears. |
Little Steven |
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Spawns a familiar that follows Isaac around and fires homing tears. |
Loki's Horns |
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Gives a random chance for projectiles to fire in all 4 cardinal directions. |
Lord Of The Pit |
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Grants flight. |
Lost Contact |
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Every tear has a small shield which will allow it to block one enemy projectile. |
Lucky Foot |
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+1 Luck. Increases chance of winning Shell Game Beggar. (Independent of luck stat) |
The Ludovico Technique |
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Instead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy. |
A Lump Of Coal |
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The more distance tears travel, the more damage they will do. |
Lunch |
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Adds 1 Heart Container. |
Maggy's Bow |
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Gives one heart container and doubles the healing provided by red hearts. |
Magic 8 Ball |
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Increases Shot Speed, and drops a Tarot Card when picked up. |
Magic Mushroom |
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Increases all stats and enlargens Isaac |
Magic Scab |
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Increases luck and HP by 1. |
Magneto |
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Pulls Pick Ups towards Isaac. |
The Mark |
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Increases Damage and Speed, plus adds one Soul Heart. |
Match Book |
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Grants Isaac 1 Black Heart and 3 bombs. Can also give troll bombs. |
MEAT! |
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Adds a heart container, and increases damage. |
Midas' Touch |
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Enemies that touch you are stunned and turn gold. Any enemy killed while in this state will drop a coin. |
The Mind |
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Grants the combined effects of the Blue Map, Treasure Map and The Compass, revealing the floor layout and all special rooms, including Secret Rooms and Super Secret Rooms. |
Mini Mush |
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Increases Speed and Range. |
Missing Page 2 |
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Gives 1 black heart. Chance to inflict The Necronomicon effect upon taking damage. |
Missing No. |
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Randomizes all passive items upon pickup and at the start of each succeeding floor. |
Mitre |
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Grants a chance of converting any red hearts pickups into soul hearts instead. |
Mom's Coin Purse |
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Spawns 4 random Pills around Isaac. |
Mom's Contacts |
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Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. |
Mom's Eye |
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Allows Isaac to fire tears from the back of his head. |
Mom's Eyeshadow |
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Tears have a chance to charm enemies. |
Mom's Heels |
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Increases range. |
Mom's Key |
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Spawns 2 keys. Generates additional pickups from chests. |
Mom's Knife |
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Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power. |
Mom's Lipstick |
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Increases range. |
Mom's Perfume |
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Adds a chance to shoot fear tears and increases Tears by 0.16. |
Mom's Purse |
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Allows Isaac to hold 1 additional trinket. |
Mom's Underwear |
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Increases range. |
Mom's Wig |
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Randomly spawn up to 5 blue spiders when firing tears |
Money = Power |
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Increases damage by 0.04 for every coin Isaac has up to +3.96 damage at 99 coins. |
Mongo Baby |
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Summons a Familiar that copies the tears of another familiar following Isaac. If no other familiars are present, Mongo Baby will fire normal tears. |
Monstro's Lung |
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Increases damage and grants a charged shot that fires multiple tears in the same fashion as Monstro. |
Mr. Mega |
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Gives Isaac 5 bombs, and makes all dropped bombs larger, which have an increased blast radius and increased damage. |
The Mulligan |
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Grants an infestation shot with a 1/6 chance of spawning allied blue flies when tears hit an enemy. |
Mutant Spider |
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Grants a quadruple shot but decreases tears. |
My Reflection |
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Gives Isaac's tears a boomerang effect, and sets range to default. |
Mysterious Liquid |
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Tears leave a small, short lasting pool of creep on impact or when their range is depleted. |
Mystery Sack |
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Spawns a familiar that follows Isaac around and has a chance to drop a heart, coin, bomb, or key after clearing a room. |
Number One |
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Tears range is heavily decreased, but the fire rate is greatly increased. |
Odd Mushroom (Large) |
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Grants an empty heart container. Increases damage, range and shot height while reducing speed. |
Odd Mushroom (Thin) |
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Increases Tears and Speed while reducing Damage. |
Old Bandage |
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Adds one empty heart container. Whenever Isaac takes damage there's a chance that a Red Heart may drop. |
Ouija Board |
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Grants spectral tears that travel through obstacles (but not enemies) instead of breaking on impact with them. |
The Pact |
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Increases damage by 0.5, tears by 0.7 and grants two soul hearts upon pickup. |
Pageant Boy |
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Spawns several coins around Isaac. |
The Parasite |
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Makes the Isaac's tears split in two when they hit something. |
The Peeper |
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Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to boom flies damaging enemies it passes through. |
Pentagram |
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Increases Damage and increases chances of the Devil Room appearing. |
PHD |
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Converts all bad pills into good pills, spawns one pill pickup and restores health. Identifies all pills upon pickup. |
Pisces |
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Increases tears and adds knock-back shots. |
Piggy Bank |
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Gives 3 pennies on pick-up. Every time Isaac is damaged, he will drop one additional penny. |
Placenta |
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Regeneration, and increases HP by 1. |
Polyphemus |
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Makes Isaac shoot one huge tear. Also reduces Tears to minimum. Damage increased . If tear does more damage than an enemy's life, the tear continues to travel with the extra remaining damage. |
Proptosis |
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Tears start out massive with high damage, and then shrink down and become weaker over a short range. |
Punching Bag |
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Spawns a Mulligan Familiar that will wander the room randomly. Enemies will attack the Mulligan if it's closer. |
Pyro |
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Adds 99 bombs. |
Pyromaniac |
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Isaac heals 1 heart instead of taking damage by a explosive blast from source. Adds 5 bombs. |
A Quarter |
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Gives you 25 cents. |
Rainbow
Baby |
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Spawns a familiar that follows Isaac around and fires
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